Andreasen N C
Mental Health Clinical Research Center, University of Iowa College of Medicine, Iowa City 52242, USA.
Can J Psychiatry. 1997 Feb;42(1):27-33. doi: 10.1177/070674379704200104.
Explaining the diversity of symptoms that occur in schizophrenia is a major conceptual challenge. Perhaps the most powerful strategy is to identify a fundamental cognitive process and/or a fundamental neural circuit.
Convergent data from our research group in Iowa and from investigators in other centres are summarized.
The thalamus plays a key role in information processing. A defect in circuitry connecting the thalamus, frontal cortex, and cerebellum could explain a wide range of symptoms. Neuropathology and imaging studies suggest that patients with schizophrenia may have abnormalities in this circuitry.
The fundamental deficit in schizophrenia may be conceptualized as a "cognitive dysmetria" characterized by impairments in coordinating the perception, encoding, retrieval, and prioritization of experience and information.
解释精神分裂症中出现的症状多样性是一个重大的概念性挑战。或许最有效的策略是识别一个基本的认知过程和/或一个基本的神经回路。
总结了来自爱荷华州我们研究小组以及其他中心研究人员的汇聚数据。
丘脑在信息处理中起关键作用。连接丘脑、额叶皮质和小脑的神经回路缺陷可以解释广泛的症状。神经病理学和影像学研究表明，精神分裂症患者可能在这个神经回路中存在异常。
精神分裂症的基本缺陷可被概念化为一种“认知失调”，其特征是在协调经验和信息的感知、编码、检索及优先级方面存在障碍。
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