Cohn M A, Kramerov D, Hulgaard E F, Lukanidin E M
Danish Cancer Society, Department of Molecular Cancer Biology, Copenhagen.
FEBS Lett. 1997 Feb 17;403(2):181-5. doi: 10.1016/s0014-5793(97)00050-1.
We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed.
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