Ueno N, Oh-ishi S, Kizaki T, Nishida M, Ohno H
Department of Public Health, Juntendo University, School of Medicine, Tokyo, Japan.
Res Commun Mol Pathol Pharmacol. 1997 Jan;95(1):92-104.
Brown adipose tissue (BAT) of obese animals is generally in a relatively atrophied and thermogenically quiescent state. The aim of the current study was to investigate the effect of swimming training on BAT activity in lean and obese (ob/ob) mice. The trained mice underwent a 6-week endurance swimming training (1 h/day, 5 days/week) in water at 35-36 degrees C. The swimming training significantly increased BAT mass and its protein content in both the lean and obese mice, suggesting hypertrophy. After swimming training, the amounts of protein and guanosine 5'-diphosphate binding in the mitochondria recovered from BAT of both mice increased significantly as compared with the respective sedentary groups, whereas the uncoupling protein (UCP) content increased significantly only in lean mice. After swimming training, the level of UCP mRNA expression did not change substantially in lean mice but appeared to increase in obese mice. The results obtained here suggest that swimming training leads to an increase in the nonshivering thermogenesis of obese mice in addition to lean mice.
肥胖动物的棕色脂肪组织（BAT）通常处于相对萎缩且产热静止的状态。本研究的目的是调查游泳训练对瘦小鼠和肥胖（ob/ob）小鼠BAT活性的影响。训练小鼠在35 - 36摄氏度的水中进行为期6周的耐力游泳训练（每天1小时，每周5天）。游泳训练显著增加了瘦小鼠和肥胖小鼠的BAT质量及其蛋白质含量，提示肥大。游泳训练后，与各自的久坐组相比，从两种小鼠的BAT中回收的线粒体中蛋白质和鸟苷5'-二磷酸结合量显著增加，而解偶联蛋白（UCP）含量仅在瘦小鼠中显著增加。游泳训练后，UCP mRNA表达水平在瘦小鼠中基本没有变化，但在肥胖小鼠中似乎有所增加。此处获得的结果表明，游泳训练除了能增加瘦小鼠的非寒战产热外，还能增加肥胖小鼠的非寒战产热。
