Burling T A, Salvio M A, Seidner A L, Ramsey T G
Palo Alto VA Health Care System, Domiciliary Service, CA 94304, USA.
J Subst Abuse. 1996;8(4):445-52. doi: 10.1016/s0899-3289(96)90005-x.
This study compared the cigarette smoking of substance abusers whose primary substance of abuse was cocaine (cocaine group: n = 18) or alcohol (alcohol group: n = 23). Cigarette smoking and smoking topography was assessed daily (via self-report and single cigarette topography assessments) at baseline and following a switch to a cigarette brand with 30% lower nicotine. The alcohol and cocaine groups did not differ at baseline on cigarettes smoked per day, cigarette nicotine, smoking topography, or the Fagerstrom Tolerance Questionnaire. However, the cocaine group exhibited marked increases in compensatory smoking relative to the alcohol group following the 30% reduction in cigarette nicotine, as evidenced by decreases in the average time interval between each puff, p < .05, increases in the total amount of time spent puffing, p < .05, and increases in estimated total amount of time spent puffing per day, p < .05. These findings provide initial data that cocaine and alcohol abusers may titrate nicotine differently and suggest that cocaine abusers may require additional or modified smoking cessation treatments.
本研究比较了主要滥用物质为可卡因的药物滥用者（可卡因组：n = 18）和主要滥用物质为酒精的药物滥用者（酒精组：n = 23）的吸烟情况。在基线时以及改用尼古丁含量低30%的香烟品牌后，每天（通过自我报告和单支香烟吸烟行为评估）评估吸烟情况和吸烟行为特征。酒精组和可卡因组在基线时，每日吸烟量、香烟尼古丁含量、吸烟行为特征或法格斯特罗姆耐受问卷得分并无差异。然而，在香烟尼古丁含量降低30%后，可卡因组相对于酒精组出现了明显的代偿性吸烟增加，表现为每次抽吸之间的平均时间间隔缩短（p < .05）、抽吸总时间增加（p < .05）以及估计每日抽吸总时间增加（p < .05）。这些研究结果提供了初步数据，表明可卡因滥用者和酒精滥用者对尼古丁的调节方式可能不同，并提示可卡因滥用者可能需要额外的或改良的戒烟治疗。
