Spieker C, Barenbrock M, Rahn K H
Medizinische Poliklinik, Unversität Münster/Westf.
Fortschr Med. 1996 Nov 20;114(32):425-30.
The role of hypertension as a major risk factor for cardio- and cerebrovascular events is well known. Various studies have shown that rigorous antihypertensive treatment can clearly reduce both cerebrovascular and cardiovascular mortality. In recent years, the therapeutic aims of antihypertensive treatment have undergone considerable changes, and to the pre-eminent aim of blood pressure reduction has been added organ protection, which is now a major effect of modern antihypertensive therapy. Today, the selection of an antihypertensive agent is decided not solely on the basis of blood pressure, but to a large extent by the requirements of organ protection and the specifics of the underlying disease. To enable individually effective antihypertensive treatment, a knowledge of the pharmacological profile of the various drugs available, and of the respective broad spectrum of side effects is an important precondition. Although non-drug therapeutic measures also have a part to play in the treatment of hypertension, antihypertensive drugs remain the most important tool for treating essential arterial hypertension.
高血压作为心脑血管事件的主要危险因素，其作用众所周知。各种研究表明，严格的降压治疗可明显降低脑血管和心血管死亡率。近年来，降压治疗的目标发生了很大变化，在首要的血压降低目标基础上增加了器官保护，这如今已成为现代降压治疗的主要效果。如今，降压药物的选择不仅完全基于血压，很大程度上还取决于器官保护的需求以及基础疾病的具体情况。为了实现个体化有效的降压治疗，了解各种可用药物的药理学特征以及各自广泛的副作用是一个重要前提。尽管非药物治疗措施在高血压治疗中也发挥一定作用，但降压药物仍然是治疗原发性高血压最重要的工具。
