肝细胞生长因子对大鼠全身照射所致骨髓抑制无作用。
Lack of effect of hepatocyte growth factor on bone marrow suppression induced by total body irradiation in the rat.
作者信息
Yamazaki H, Inoue T, Tang J T, Nose T, Koizumi M, Tanaka E, Teshima T, Ozeki S, Nakamura H, Inoue T
机构信息
Department of Radiation Oncology, Osaka University Medical School, Japan.
出版信息
Anticancer Res. 1997 Jan-Feb;17(1A):479-80.
We examined the role of hepatocyte growth factor (HGF) on the bone marrow suppression by irradiation, by analyzing peripheral blood counts 2 weeks after 7 Gy of total body irradiation in rats. The rats underwent two weeks of continuous intraperitoneal human recombinant HGF injection (50 mg/day) from one day before irradiation using an Alzet osmotic pump. Red blood cell, white blood cell, and platelet counts did not increase with response to administration of HGF. Thus HGF does not show protection against myelosuppression caused by total body irradiation.
我们通过分析大鼠接受7 Gy全身照射后2周的外周血细胞计数，研究了肝细胞生长因子（HGF）在辐射引起的骨髓抑制中的作用。从照射前一天开始，使用Alzet渗透泵对大鼠进行为期两周的连续腹腔内注射人重组HGF（50 mg/天）。红细胞、白细胞和血小板计数并未因HGF的给药而增加。因此，HGF对全身照射引起的骨髓抑制没有保护作用。
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