在SHR和唐鱼大鼠的回交分析中，增强的Ca2+动员是一种与“主基因”相区别的高血压性状。

Augmented Ca2+ mobilization is a hypertensive trait discriminated from a 'major gene' in backcross analysis between SHR and Donryu rats.

Ohno Y, Suzuki H, Matsuo K, Tanase H, Takano T, Saruta T

Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S220-2. doi: 10.1111/j.1440-1681.1995.tb02890.x.

Abstract

Blood pressure and Ca2+ mobilization were significantly greater in SHR than in Donryu and F1 rats. 2. Backcross linkage analysis between spontaneously hypertensive rats and normotensive Donryu rats was performed to dissect polygenic hypertensive traits and to detect the existence of a single 'major gene'. 3. Cluster and discriminant analysis of a scattergram of blood pressure versus Ca2+ mobilization classified the backcrossed rats into two groups. The two groups were referred to the higher group and the lower group with regard to their relative blood pressure values. 4. Blood pressure was correlated with Ca2+ mobilization in each group; the correlation coefficients were 0.41 for the higher group (P < 0.01) and 0.71 for the lower group (P < 0.0001).

摘要

自发性高血压大鼠（SHR）的血压和钙离子动员显著高于东乡大鼠和F1大鼠。2. 对自发性高血压大鼠和血压正常的东乡大鼠进行回交连锁分析，以剖析多基因高血压性状并检测单个“主基因”的存在。3. 根据血压与钙离子动员散点图进行聚类和判别分析，将回交大鼠分为两组。就相对血压值而言，这两组分别称为较高组和较低组。4. 每组中血压与钙离子动员均相关；较高组的相关系数为0.41（P<0.01），较低组的相关系数为0.71（P<0.0001）。