D'Alessandro Gandolfo L, Griso D, Macrì A, Biolcati G, Barlattani A, Topi G C
Laboratory of Biochemistry, San Gallicano Dermatological Institute, Rome, Italy.
Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):75-9.
In order to evaluate the pathogenetic role of iron in Porphyria cutanea tarda (PCT), the metabolism of iron was studied in 440 patient with PCT and associated chronic liver disease (CLD) and in 91 nonporphyric CLD patients (used as a control group). The parameters considered were the following: serum iron, ferritin, Total Iron Binding Capacity (TIBC) and percent saturation of transferrin. The statistical analysis showed that the differences between the means, in the two groups, were not significant in any of the parameters examined. To investigate the possible relationships between iron metabolism and other chemico-clinical parameters concerning the porphyric disease, the associated hepatic disease and hemometry, we studied the correlations between iron parameters and total urinary and serum porphyrins, serum copper, serum albumin, hemoglobin, red blood cells, ALT, AST, CHE and GLDH. This investigation was only possible in the last 99 cases. In addition to the obvious correlations between the parameters concerning iron metabolism, the highly significant (p < 0.001) correlation between ferritin and enzyme activities which indicate cytolysis (ALT, AST, GLDH) is extremely interesting. The results seem to point to the tentative conclusion that the alterations of iron metabolism are more related to the hepatocellular necrosis than to the metabolism of porphyrins.
为了评估铁在迟发性皮肤卟啉症（PCT）发病机制中的作用，我们对440例PCT合并慢性肝病（CLD）患者及91例非卟啉症CLD患者（作为对照组）的铁代谢进行了研究。所考虑的参数如下：血清铁、铁蛋白、总铁结合力（TIBC）及转铁蛋白饱和度百分比。统计分析表明，两组均值在任何检测参数上的差异均无统计学意义。为了研究铁代谢与卟啉病、相关肝病及血液学方面的其他化学临床参数之间的可能关系，我们研究了铁参数与尿及血清总卟啉、血清铜、血清白蛋白、血红蛋白、红细胞、谷丙转氨酶（ALT）、谷草转氨酶（AST）、胆碱酯酶（CHE）及谷氨酸脱氢酶（GLDH）之间的相关性。该研究仅在最后99例病例中得以进行。除了铁代谢相关参数之间的明显相关性外，铁蛋白与提示细胞溶解的酶活性（ALT、AST、GLDH）之间高度显著（p < 0.001）的相关性极其有趣。结果似乎指向一个初步结论，即铁代谢改变与肝细胞坏死的关系比与卟啉代谢的关系更为密切。
