二丁酰环磷腺苷对正常人和原发性醛固酮增多症患者血浆肾素活性的影响。

Effect of dibutyryl cyclic AMP on plasma renin activity in normal men and patients with primary aldosteronism.

作者信息

Fukuda N, Soma M, Kubo A, Kunimoto M, Watanabe Y, Izumi Y, Kanmatsuse K

机构信息

Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

出版信息

J Endocrinol Invest. 1997 Jan;20(1):13-7. doi: 10.1007/BF03347966.

DOI:10.1007/BF03347966

PMID:9075066

Abstract

Dibutyryl cyclic AMP (DBcAMP) directly stimulates the release of renin from the juxtaglomerular (JG) cells in vitro. We investigated the effect of DBcAMP on plasma renin activity (PRA) in 6 normal men and in 8 patients with primary aldosteronism (PA). A 20-min infusion of 0.33 mg/kg/min of DBcAMP significantly increased PRA in normal men, but had little effect on PRA in patients with PA. Infusion of DBcAMP significantly reduced the blood pressure and the levels of serum sodium and potassium in normal men and the patients with PA. Infusion of DBcAMP significantly increased urine volume in normal men, but not in patients with PA. Urinary excretion of sodium increased in both groups after the infusion of DBcAMP. Thus, DBcAMP did not stimulate renin release in patients with PA, suggesting that the chronic excess production of aldosterone suppresses the release of renin from JG cells.

摘要

二丁酰环磷腺苷（DBcAMP）在体外可直接刺激球旁（JG）细胞释放肾素。我们研究了DBcAMP对6名正常男性和8例原发性醛固酮增多症（PA）患者血浆肾素活性（PRA）的影响。以0.33mg/kg/min的速度输注DBcAMP 20分钟，可显著提高正常男性的PRA，但对PA患者的PRA影响不大。输注DBcAMP可显著降低正常男性和PA患者的血压以及血清钠和钾水平。输注DBcAMP可显著增加正常男性的尿量，但对PA患者无效。输注DBcAMP后两组的尿钠排泄均增加。因此，DBcAMP不能刺激PA患者的肾素释放，提示醛固酮的长期过量分泌抑制了JG细胞肾素的释放。