Compri M B, Polimeno N C, Stella M B, Ramalho A S
Departamento de Ciências Fisiológicas da Faculdade de Ciências Médicas da Universidade São Francisco, Bragança, Paulista, Brasil.
Rev Saude Publica. 1996 Apr;30(2):187-95. doi: 10.1590/s0034-89101996000200011.
This study tested the viability and efficiency of a hereditary hemoglobinopathy program in which a Brazilian community the town of Bragança Paulista, SP (Brazil)-was involved, were tested focusing school students. The screening of the hemoglobinopathies was done through optional exams for patients by using electrophoresis of hemoglobins and complementary hematological tests. A total of 1,171 individuals, including, 1,118 pupils and 53 of their relatives were tested over a period of 24 months. A total of 47 individuals with hereditary hemoglobin changes were detected-4.0% of the samples examined. The community was fairly receptive to the program which showed a general level of acceptance of 55.4%. The study aroused the interest of the community and motivated the implantation of a special service for diagnosis, genetic counseling and treatment of the hemoglobinopathy carriers in the community where it was undertaken.
本研究测试了一项遗传性血红蛋白病项目的可行性和效率,该项目涉及巴西圣保罗州布拉干萨保利斯塔镇的一个社区,以在校学生为测试对象。通过血红蛋白电泳和补充血液学检测等可选检查对血红蛋白病进行筛查。在24个月的时间里,共对1171人进行了检测,其中包括1118名学生及其53名亲属。共检测出47例遗传性血红蛋白改变个体,占所检查样本的4.0%。该社区对该项目相当接受,总体接受率为55.4%。该研究引起了社区的兴趣,并促使在开展研究的社区建立了一项针对血红蛋白病携带者的诊断、遗传咨询和治疗的特殊服务。