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[Apolipoprotein (a)].[载脂蛋白(a)]
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A proximal tissue-specific module and a distal negative regulatory module control apolipoprotein(a) gene transcription.一个近端组织特异性模块和一个远端负调控模块控制载脂蛋白(a)基因的转录。
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A NEW SERUM TYPE SYSTEM IN MAN--THE LP SYSTEM.人类的一种新血清类型系统——LP系统。
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Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production.具有相同载脂蛋白(a)异构体的个体之间脂蛋白(a)浓度的差异由脂蛋白(a)的产生速率决定。
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The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.血浆脂蛋白(a)浓度与载脂蛋白(a)异构体大小的负相关并非由于脂蛋白(a)分解代谢的差异，而是由于生成速率的差异。
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4
Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common "null" allele at the apo(a) locus.三个种族群体中载脂蛋白(a)基因、载脂蛋白(a)糖蛋白及脂蛋白(a)血浆浓度的比较分析。载脂蛋白(a)位点不存在共同“无效”等位基因的证据。
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Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles.脂蛋白(a)浓度的变化与不同的载脂蛋白(a)等位基因相关。
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6
Lipoprotein(a) in restenosis after percutaneous transluminal coronary angioplasty and coronary artery disease.经皮腔内冠状动脉成形术后再狭窄和冠状动脉疾病中的脂蛋白(a)
Circulation. 1994 Apr;89(4):1593-8. doi: 10.1161/01.cir.89.4.1593.
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Evidence that apolipoprotein(a) phenotype is a risk factor for coronary artery disease in men < 55 years of age.
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Apolipoprotein(a) gene transcription is regulated by liver-enriched trans-acting factor hepatocyte nuclear factor 1 alpha.
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Induction of translation by the 5'-untranslated region of human androgen receptor mRNA.人雄激素受体mRNA的5'-非翻译区对翻译的诱导作用。
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10
Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma.载脂蛋白(a)基因中的序列多态性与血浆中特定水平的脂蛋白(a)相关。
Hum Mol Genet. 1995 Feb;4(2):173-81. doi: 10.1093/hmg/4.2.173.

血浆脂蛋白(a)水平及载脂蛋白(a)基因的表达取决于其5'-侧翼区域的核苷酸多态性。

Plasma lipoprotein(a) levels and expression of the apolipoprotein(a) gene are dependent on the nucleotide polymorphisms in its 5'-flanking region.

作者信息

Suzuki K, Kuriyama M, Saito T, Ichinose A

机构信息

Department of Molecular Pathological Biochemistry, Yamagata University School of Medicine, Japan.

出版信息

J Clin Invest. 1997 Mar 15;99(6):1361-6. doi: 10.1172/JCI119295.

DOI:10.1172/JCI119295
PMID:9077546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC507952/
Abstract

The apolipoprotein(a) (apo[a]) gene encodes a protein component of lipoprotein(a) [Lp(a)] whose plasma levels vary widely among individuals. Hyper-Lp(a)-emia constitutes a risk factor for thromboembolic disease. We previously subclassified the apo(a) gene into four allelic types (A-D) by polymorphisms in the 5'-flanking region. To elucidate whether these polymorphisms affect the expression of apo(a), we measured plasma Lp(a) concentrations in vivo by ELISA and examined expression of the gene by an in vitro assay using its 5'-flanking region. Homozygotes of type C had significantly higher Lp(a) levels than those of type D. The relative expression of type C was also about three times higher than that of type D, which was consistent with the in vivo results. Deletion analysis revealed that the substitution of C by T (+93) led to negative regulation in expression of the gene, while the change of G to A (+121) led to positive regulation. These results indicate that the polymorphisms in the 5'-flanking region of the apo(a) gene affect the efficiency of its expression and, in part, play a role in regulating plasma Lp(a) levels.

摘要

载脂蛋白(a)[apo(a)]基因编码脂蛋白(a)[Lp(a)]的一种蛋白质成分，其血浆水平在个体间差异很大。高Lp(a)血症是血栓栓塞性疾病的一个危险因素。我们之前通过5'-侧翼区域的多态性将apo(a)基因分为四种等位基因类型(A-D)。为了阐明这些多态性是否影响apo(a)的表达，我们通过酶联免疫吸附测定(ELISA)在体内测量了血浆Lp(a)浓度，并使用其5'-侧翼区域通过体外试验检测了该基因的表达。C型纯合子的Lp(a)水平显著高于D型。C型的相对表达也比D型高约三倍，这与体内结果一致。缺失分析表明，T取代C(+93)导致该基因表达的负调控，而G变为A(+121)导致正调控。这些结果表明，apo(a)基因5'-侧翼区域的多态性影响其表达效率，并在一定程度上对调节血浆Lp(a)水平起作用。