Roest J, Mous H V, Zeilmaker G H, Verhoeff A
Department of Obstetrics and Gynaecology, Zuiderziekenhuis, Rotterdam, The Netherlands.
Hum Reprod Update. 1996 Jul-Aug;2(4):345-53. doi: 10.1093/humupd/2.4.345.
Four different major clinical complications were identified in a retrospective analysis of 2495 in-vitro fertilization (IVF) cycles resulting in oocyte retrieval. The severe form of ovarian hyperstimulation syndrome (OHSS) occurred in 18 patients, giving a prevalence for this complication of 0.7%. Seven (39%) of these 18 patients had previously been diagnosed as having polycystic ovaries. Eleven patients were admitted with moderate OHSS. Adnexal torsion was diagnosed in two patients. Ovariectomy was considered necessary in both cases. Complications of the transvaginal procedure occurred in seven cases (0.3%): one patient had an acute appendicitis with puncture holes in the appendix, six patients were admitted shortly after oocyte retrieval with a pelvic inflammatory disease. Of the 624 pregnancies obtained, 13 were ectopic, giving an ectopic pregnancy rate of 2.1%. It is concluded that serious clinical complications of IVF treatment are rare. However, patients should be counselled for the occurrence of serious procedure-related complications before entering an IVF programme.
在一项对2495个取卵的体外受精（IVF）周期进行的回顾性分析中，确定了四种不同的主要临床并发症。严重形式的卵巢过度刺激综合征（OHSS）发生在18例患者中，该并发症的发生率为0.7%。这18例患者中有7例（39%）先前被诊断为患有多囊卵巢。11例患者因中度OHSS入院。两名患者被诊断为附件扭转。在这两例中均认为有必要进行卵巢切除术。经阴道手术的并发症发生在7例（0.3%）：1例患者患有急性阑尾炎，阑尾有穿刺孔，6例患者在取卵后不久因盆腔炎入院。在获得的624例妊娠中，有13例为异位妊娠，异位妊娠率为2.1%。结论是IVF治疗的严重临床并发症很少见。然而，在进入IVF计划之前，应向患者咨询与手术相关的严重并发症的发生情况。
