Michalopoulos G K, DeFrances M C
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Science. 1997 Apr 4;276(5309):60-6. doi: 10.1126/science.276.5309.60.
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. Many growth factors and cytokines, most notably hepatocyte growth factor, epidermal growth factor, transforming growth factor-alpha, interleukin-6, tumor necrosis factor-alpha, insulin, and norepinephrine, appear to play important roles in this process. This review attempts to integrate the findings of the last three decades and looks toward clues as to the nature of the causes that trigger this fascinating organ and cellular response.
肝组织丧失后的肝脏再生是肝脏对损伤反应的一个基本参数。自神话时代起就被视作一种现象，如今它被定义为由特定外部刺激诱导的一种精心编排的反应，涉及基因表达、生长因子产生和形态结构的一系列变化。许多生长因子和细胞因子，最显著的是肝细胞生长因子、表皮生长因子、转化生长因子-α、白细胞介素-6、肿瘤坏死因子-α、胰岛素和去甲肾上腺素，似乎在这一过程中发挥着重要作用。本综述试图整合过去三十年的研究结果，并探寻引发这种迷人的器官和细胞反应的原因的本质线索。
