Berner R, Leititis J U, Fürste H O, Brandis M
University of Children's Hospital, Freiburg, Germany.
Eur J Pediatr. 1997 Mar;156(3):207-8. doi: 10.1007/s004310050584.
Diphtheria has become a rare disease in Germany. We report on an unimmunized 3.5-year-old German girl with a 7-day history of respiratory distress and fever, presenting a clinical picture mimicking typical bacterial tracheitis without pharyngeal and laryngeal manifestation. Diagnosis of diphtheria was not made until culture of tracheal secretions yielded growth of a toxigenic strain of Corynebacterium diphtheriae. The patient died from toxic cardiac failure despite treatment with diphtheria antitoxin. This is the second reported case of isolated bacterial tracheitis caused by Corynebacterium diphtheriae.
The observation of a lethal course of diphtheric tracheitis emphasizes the paramount importance of immunization against diseases like diphtheria.
白喉在德国已成为一种罕见疾病。我们报告了一名3.5岁未接种疫苗的德国女孩,她有7天的呼吸窘迫和发热病史,临床表现类似典型的细菌性气管炎,但无咽部和喉部表现。直到气管分泌物培养出产毒白喉棒状杆菌菌株,才确诊为白喉。尽管使用了白喉抗毒素治疗,患者仍死于中毒性心力衰竭。这是第二例报告的由白喉棒状杆菌引起的孤立性细菌性气管炎病例。
白喉性气管炎致死病程的观察强调了针对白喉等疾病进行免疫接种的至关重要性。