Ultrasound-guided stent placement.

IVUS imaging has dramatically increased understanding of the process of coronary stent placement. Preintervention or diagnostic IVUS has been shown to be of value before stent placement to assess lesion severity and length as well as the degree and location of calcification. Before stent placement, ultrasound dimensions may also be used to select the appropriate type and size of device. Although studies are in progress to define the role of prestent ultrasound imaging, much interest centers around the use of IVUS to detect significant superficial coronary calcium and direct rotational atherectomy before stent placement. Clinical trials have demonstrated the feasibility and safety of IVUS-guided coronary stent placement without postprocedure warfarin anticoagulation. Although it has been established subsequently that reduced anticoagulation may be administered to low-risk patients without IVUS guidance, three important points have been established by these trials. First, IVUS is superior to angiography for assessment of adequate stent expansion and apposition. As noted in several studies, angiography frequently overestimates lumen dimensions after stent placement. Second, IVUS-guided stent implantation yields larger acute stent dimensions. Third, IVUS-guided therapy in the form of additional stent placement or use of a larger balloon does not increase stent procedure complication rates when appropriate criteria for optimal stent placement are used. A randomized clinical trial (AVID) of angiography-directed versus IVUS-directed coronary stent placement is in progress (with a second soon to begin enrollment). In this trial, ultrasound guidance has been shown to improve acute procedural results, providing larger lumen dimensions without an increase in complication rates. IVUS guidance, however does not appear to affect the incidence of stent thrombosis within 30 days in the present era of high-pressure balloon inflations and aggressive antiplatelet therapy. Results concerning the effect of ultrasound-guided therapy on long-term target lesion revascularization rates are pending. To date, IVUS imaging has greatly contributed to advancements in coronary stent placement techniques. The future of IVUS-guided coronary stent placement will, of course, depend on the results of several ongoing clinical trials.