Joe B, Rao U J, Lokesh B R
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, India.
Mol Cell Biochem. 1997 Apr;169(1-2):125-34. doi: 10.1023/a:1006877928703.
Levels of various serum proteins were found to change in adjuvant induced arthritis. Increased levels of a glycoprotein with an apparent molecular weight of 72 kDa (Gp A72) were observed in the sera of arthritic rats. Gp A72 is an acidic glycoprotein with a pI of 5.1. Gp A72 also showed antitryptic activity. The appearance of Gp A72 in the serum preceded the onset of paw inflammation in arthritic rats and persisted in the chronic phase. Oral administration of the antiinflammatory spice principles-capsaicin (from red pepper) and curcumin (from turmeric) lowered the levels of Gp A72 by 88 and 73% respectively with concomitant lowering of paw inflammation in arthritic rats.
在佐剂诱导的关节炎中，发现各种血清蛋白水平发生变化。在患关节炎大鼠的血清中观察到一种表观分子量为72 kDa的糖蛋白（Gp A72）水平升高。Gp A72是一种pI为5.1的酸性糖蛋白。Gp A72还表现出抗胰蛋白酶活性。Gp A72在血清中的出现先于患关节炎大鼠爪部炎症的发作，并在慢性期持续存在。口服抗炎香料成分——辣椒素（来自红辣椒）和姜黄素（来自姜黄）可使Gp A72水平分别降低88%和73%，同时患关节炎大鼠爪部炎症也随之减轻。
