Ganley J P, Fontenot K
Department of Ophthalmology, Louisiana State University Medical Center-Shreveport, USA.
Arch Ophthalmol. 1997 Apr;115(4):537-41. doi: 10.1001/archopht.1997.01100150539017.
To identify common risk factors that might be associated with a cluster of 4 cases of choroidal malignant melanoma that occurred in a manufacturing plant between 1982 and 1985.
Survey of choroidal malignant melanoma cases in Caddo and Bossier parishes during the same time frame.
We identified 4 additional individuals with choroidal malignant melanoma first diagnosed during the study period. Characteristics of the workplace were examined and a questionnaire was administered to all subjects to ascertain exposures to putative carcinogens and to putative risk factors for intraocular malignant melanoma. Observed and expected incidence rates were calculated.
The overall incidence of intraocular malignant melanoma for the 2 parishes during the 4-year period was 0.56 cases per 100,000 population per year, similar to the expected rates for this population. The incidence rate for the manufacturing plant employees was 16.5 cases per 100,000 per year. The mean age at diagnosis for workers at the plant was 38.7 years compared with 69.2 years for nonplant employees.
The close occurrence of manufacturing plant cases in time and space and the younger age of the people are consistent with a cluster of intraocular melanoma cases. No specific risk factors were found in the workplace environment to impute a causal association.
确定可能与1982年至1985年期间一家制造厂发生的4例脉络膜恶性黑色素瘤聚集病例相关的常见风险因素。
对同一时期卡多教区和博西尔教区的脉络膜恶性黑色素瘤病例进行调查。
我们确定了另外4名在研究期间首次被诊断为脉络膜恶性黑色素瘤的个体。检查工作场所的特征，并向所有受试者发放问卷，以确定其接触假定致癌物和眼内恶性黑色素瘤假定风险因素的情况。计算观察到的发病率和预期发病率。
这两个教区在4年期间眼内恶性黑色素瘤的总体发病率为每年每10万人0.56例，与该人群的预期发病率相似。该制造厂员工的发病率为每年每10万人16.5例。该厂工人诊断时的平均年龄为38.7岁，而非该厂员工为69.2岁。
制造厂病例在时间和空间上的紧密发生以及人群的年轻化与眼内黑色素瘤病例的聚集相符。在工作场所环境中未发现可归因于因果关系的特定风险因素。
