Hodges L C, Reggio P H, Green K
Department of Chemistry, Agnes Scott College, Decatur, Ga. 30030, USA.
Ophthalmic Res. 1997;29(1):1-5. doi: 10.1159/000267984.
Cannabinoid receptor involvement in the intraocular-pressure (IOP)-lowering effect of the cannabinoids has not been determined. These receptors bind four structural classes of agonists: the classical and the nonclassical cannabinoids, the aminoalkylindoles and the arachidonylethanolamides (the endogenous ligands). We examined the IOP effect in normotensive rabbits after systemic administration of an aminoalkylindole, WIN-55,212-2, and of (R)-(+)-methanandamine, a hydrolysis-resistant endogenous ligand derivative. The decrease in IOP for 6 animals treated with WIN-55,212-2 was marginal and for 6 animals treated with (R)-(+)-methanandamide was negligible compared to animals treated with vehicle alone. These studies suggest that the IOP-lowering effects of cannabinoids are not mediated by a cannabinoid receptor in rabbits.
大麻素受体是否参与大麻素降低眼内压（IOP）的作用尚未确定。这些受体可结合四种结构类型的激动剂：经典和非经典大麻素、氨基烷基吲哚和花生四烯酸乙醇酰胺（内源性配体）。我们在正常血压的兔子全身给药氨基烷基吲哚WIN-55,212-2和一种抗水解的内源性配体衍生物（R）-（+）-甲胺大麻素后，检测了眼内压的变化。与仅用赋形剂处理的动物相比，用WIN-55,212-2处理的6只动物眼内压的降低幅度很小，用（R）-（+）-甲胺大麻素处理的6只动物眼内压的降低可忽略不计。这些研究表明，大麻素降低眼内压的作用在兔子中不是由大麻素受体介导的。
