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Effect of glycine on antidepressant- and anxiolytic-like action of 1-aminocyclopropanecarboxylic acid (ACPC) in rats.

作者信息

Chojnacka-Wójcik E, Tatarczyńska E, Dereń-Wesołek A

机构信息

Department of New Drug Research, Polish Academy of Sciences, Kraków, Poland.

出版信息

Pol J Pharmacol. 1996 Nov-Dec;48(6):627-9.

PMID:9112704
Abstract

Glycine (800 mg/kg ip) abolished the antimmobility effect of 1-aminocyclopropanecarboxylic acid (ACPC) given both ip (400 mg/kg) and ihp (30 micrograms) in the forced swimming test in rats, but did not affect the anticonflict activity of ACPC (200 mg/kg ip or 10 micrograms ihp) in the conflict drinking test.

摘要

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1-aminocyclopropanecarboxylates exhibit antidepressant and anxiolytic actions in animal models.
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