β-内啡肽C末端肽对小鼠离体骨骼肌葡萄糖摄取的影响。

Effect of beta-endorphin C-terminal peptides on glucose uptake in isolated skeletal muscles of the mouse.

作者信息

Evans A, Smith M E

机构信息

Department of Physiology, Medical School, University of Birmingham, UK.

出版信息

Peptides. 1997;18(1):165-7. doi: 10.1016/s0196-9781(96)00241-0.

DOI:10.1016/s0196-9781(96)00241-0

PMID:9114466

Abstract

The uptake of a nonmetabolizable derivative of glucose, [3H]2-deoxy-D-glucose was examined in isolated slow (soleus) and fast (extensor digitorum longus, EDL) muscles of adult mice. An analogue of beta-endorphin (28-31), Ac-Lys-D-Lys-Sar-Glu, which is stable to proteolytic digestion, enhanced the uptake of glucose into the slow and fast muscles. The muscles of male mice were more sensitive to the peptide than those of female mice. The maximum uptake seen in the presence of the peptide was similar to that seen with insulin in the soleus muscle and greater than that seen with insulin in the EDL muscle.

摘要

在成年小鼠的离体慢肌（比目鱼肌）和快肌（趾长伸肌，EDL）中检测了葡萄糖的一种不可代谢衍生物[3H]2-脱氧-D-葡萄糖的摄取情况。一种对蛋白水解消化稳定的β-内啡肽类似物（28-31），Ac-Lys-D-Lys-Sar-Glu，增强了葡萄糖向慢肌和快肌的摄取。雄性小鼠的肌肉比雌性小鼠的肌肉对该肽更敏感。在该肽存在下观察到的最大摄取量与比目鱼肌中胰岛素作用下的摄取量相似，且大于趾长伸肌中胰岛素作用下的摄取量。