在一个协调性异种移植模型中的耐受性研究。

A study of tolerance in a concordant xenograft model.

作者信息

Bartholomew A M, Cosimi A B, Sachs D H, Bailin M, Boskovic S, Colvin R, Hong H, Johnson M, Kimikawa M, Leguern A, Meehan S, Sablinski T, Wee S L, Powelson J

机构信息

Transplant Unit, Massachusetts General Hospital, Boston, USA.

出版信息

Transplant Proc. 1997 Feb-Mar;29(1-2):923-4. doi: 10.1016/s0041-1345(96)00236-9.

DOI:10.1016/s0041-1345(96)00236-9

PMID:9123588

Abstract

Antibody-mediated rejection appears to constitute the major difference between concordant xenografts and allografts in nonhuman primates. Consistent with its known effect on antibody responses, 5-7 addition of DSG to the conditioning regimen has extended concordant primate xenograft survival for up to 6 months after discontinuation of conventional immunosuppression. In contrast to our observations in recipients of renal allografts, donor-specific skin graft rejection can occur and even in long-term recipients may induce rejection of a previously accepted renal xenograft.

摘要

抗体介导的排斥反应似乎是导致非人灵长类动物中协调性异种移植与同种异体移植存在主要差异的原因。与已知的对抗体反应的影响一致，在预处理方案中添加去唾液酸糖蛋白（DSG）可使协调性灵长类动物异种移植在停用常规免疫抑制后存活长达6个月。与我们在肾同种异体移植受者中的观察结果相反，供体特异性皮肤移植排斥反应可能会发生，甚至在长期受者中也可能引发对先前已接受的肾异种移植的排斥反应。