Kunelius P, Häkkinen J, Lukkarinen O
Surgical Clinic, University of Oulu, Finland.
Urology. 1997 Mar;49(3):441-4. doi: 10.1016/S0090-4295(96)00505-5.
To determine the effectiveness and safety of high-dose yohimbine for the treatment of mixed-type impotence.
Twenty-nine patients who had mixed-type impotence diagnosed on the basis of a sexual history, results of a physical examination, laboratory analysis, assessment of the sensory pain threshold of the dorsal nerve of the penis, and dynamic color Doppler sonography of the cavernosal arteries were entered into a randomized, double-blind, placebo-controlled, crossover comparison of a placebo with high-dose yohimbine hydrochloride (36 mg per day orally). The treatment consisted of two 25-day courses; after a 14-day washout period, the patients who initially received the placebo for 25 days were switched to yohimbine hydrochloride for 25 days. Erectile function, ejaculation, interest in sex, physical examination findings, blood pressure, pulse rate, weight, and audiovisual sexual stimulation test were investigated before treatment and at the end of each drug period. The Mann-Whitney test was used for the statistical analysis.
Twenty-seven patients (93%) completed the whole treatment schedule. Positive clinical results (complete and partial responses) were obtained in 12 cases (44%) at the end of the yohimbine phase and in 13 (48%) after the placebo period. No statistical difference was indicated. Drug-related adverse effects occurred in 2 patients in the yohimbine group (7%).
Yohimbine is no better than placebo as a first-line treatment for mixed-type impotence.
确定高剂量育亨宾治疗混合型阳痿的有效性和安全性。
29例根据性病史、体格检查结果、实验室分析、阴茎背神经感觉疼痛阈值评估以及海绵体动脉动态彩色多普勒超声检查诊断为混合型阳痿的患者，进入一项随机、双盲、安慰剂对照的交叉比较试验，比较安慰剂与高剂量盐酸育亨宾（每日口服36毫克）。治疗包括两个25天疗程；在14天的洗脱期后，最初接受25天安慰剂治疗的患者改为接受25天盐酸育亨宾治疗。在治疗前以及每个药物疗程结束时，对勃起功能、射精、性兴趣、体格检查结果、血压、脉搏率、体重以及视听性刺激试验进行调查。采用曼-惠特尼检验进行统计分析。
27例患者（93%）完成了整个治疗方案。在育亨宾治疗阶段结束时，12例患者（44%）获得了阳性临床结果（完全和部分反应），在安慰剂治疗期后有13例（48%）。未显示出统计学差异。育亨宾组有2例患者（7%）出现与药物相关的不良反应。
作为混合型阳痿的一线治疗药物，育亨宾并不比安慰剂效果更好。
