Makin A J, Hughes R D, Williams R
Institute of Liver Studies, King's College School of Medicine and Dentistry, London, UK.
Am J Physiol. 1997 Mar;272(3 Pt 1):G617-25. doi: 10.1152/ajpgi.1997.272.3.G617.
Systemic and hepatic circulatory changes were studied in rats over the course of acute liver injury. Hepatic injury was induced by intraperitoneal injection of D-galactosamine (1.1 g/kg), and systemic and hepatic hemodynamics were measured over a 72-h period using a radioactive microsphere technique with direct measurement of arterial, portal venous, and hepatic venous blood oxygen content. Cardiac output increased to a maximum at 48 h, producing a marked increase (450%) in hepatic arterial blood flow so that it became the dominant supply of oxygen at the time of maximal hepatic injury. A subsequent increase in portal venous flow resulted in an overall increase in total hepatic blood flow of 500%. At this point the oxygen delivery by the hepatic arterial and portal venous systems was equal. These circulatory changes returned to control values by 72 h with recovery of liver function. These results demonstrate the development of a hyperdynamic circulation and a marked change in the normal relationship between portal venous and hepatic arterial blood flows that occur during hepatic injury.
在急性肝损伤过程中，对大鼠的全身和肝脏循环变化进行了研究。通过腹腔注射D - 半乳糖胺（1.1 g/kg）诱导肝损伤，并使用放射性微球技术在72小时内测量全身和肝脏血流动力学，同时直接测量动脉、门静脉和肝静脉血中的氧含量。心输出量在48小时时增加到最大值，使肝动脉血流量显著增加（450%），以至于在肝损伤最严重时它成为主要的氧气供应来源。随后门静脉血流量增加，导致肝脏总血流量总体增加500%。此时，肝动脉和门静脉系统的氧输送量相等。随着肝功能的恢复，这些循环变化在72小时时恢复到对照值。这些结果表明，在肝损伤期间会出现高动力循环的发展以及门静脉和肝动脉血流之间正常关系的显著变化。
