[通过核磁共振研究与肿瘤过程相关的脑脂质组成变化]
[Study by NMR of the modifications of brain lipid composition related to the tumor processes].
作者信息
Debouzy J C, Fauvelle F, Fouilhe N, Sam-Lai E, Nemoz C, Girault L, Mazet L
机构信息
CRSSA, Service de Biophysique, La Tronche.
出版信息
Ann Pharm Fr. 1997;55(1):35-41.
PMID:9138319
Abstract
1H, 13C, 31P and 14N NMR spectroscopies were used to investigate the lipid composition of brain tumors (GL6 glioma) in rats, by comparison with controlateral hemispheres. Comparative indexes derived from NMR signal intensities were used to establish the statistical analysis. It was found that sterol metabolism and sphingolipid/glycerolipids ratio are significantly modified when a tumor is present.
摘要
采用氢核磁共振（1H NMR）、碳核磁共振（13C NMR）、磷核磁共振（31P NMR）和氮核磁共振（14N NMR）光谱技术，通过与对侧半球进行比较，研究大鼠脑肿瘤（GL6胶质瘤）的脂质组成。利用从核磁共振信号强度得出的比较指标进行统计分析。结果发现，存在肿瘤时，甾醇代谢以及鞘脂/甘油脂比率会发生显著改变。
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