[癌症与区域淋巴结（免疫组织化学和超微结构研究）]

[Cancer and the regional lymph nodes (immunohistochemical and ultrastructural studies)].

作者信息

Tsyplakov D E, Petrov S V

出版信息

Arkh Patol. 1997 Jan-Feb;59(1):12-9.

Abstract

153 regional lymph nodes obtained during surgical operations because of cancer of various cites from 50 cancer patients were studied. Failure of local immunity is explained by the following factors: 1) depletion of T-cell population with a decrease of activated lymphocyte-killers; 2) high activity of B-cell population able to block T-cell cytotoxic effect; 3) deficiency of T-suppressors and T-helpers; 4) a decrease of macrophages-monocytes of phagocytic capacity; 5) high activity of dendritic reticular cells stimulating transformation of B-lymphocytes and low activity of interdigitating reticulocytes determining T-cell immunity stimulation.

摘要

对50例癌症患者因不同部位癌症手术获取的153个区域淋巴结进行了研究。局部免疫功能衰竭可由以下因素解释：1）T细胞群耗竭，活化的淋巴细胞杀伤细胞减少；2）能够阻断T细胞细胞毒性作用的B细胞群活性高；3）T抑制细胞和T辅助细胞缺乏；4）吞噬能力的巨噬细胞-单核细胞减少；5）刺激B淋巴细胞转化的树突状网状细胞活性高，决定T细胞免疫刺激的交错突网状细胞活性低。