Bartges J W, Osborne C A, Felice L J, Koehler L A, Ulrich L K, Bird K A, Chen M
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Am J Vet Res. 1997 May;58(5):511-5.
To determine whether diet influences the metabolism of IV administered allopurinol in healthy dogs.
6 healthy female Beagles, 4.9 to 5.2 years old and weighing 9.6 to 11.5 kg.
Allopurinol was administered IV (10 mg/kg) while dogs consumed a 10.4% protein (dry weight), casein-based diet or a 31.4% (dry weight), meat-based diet. After each dose, plasma samples were obtained at timed intervals, and concentrations of allopurinol and its active metabolite, oxypurinol, were determined by high-performance liquid chromatography. An iterative, nonlinear regression analytical program was used to determine the weighted least-squares, best-fit curves for plasma allopurinol and oxypurinol concentration-time data. From these data, pharmacokinetic parameters were calculated.
Pharmacokinetic parameters for allopurinol and oxypurinol were not different when comparing the effect of diet.
There is no influence of diet on pharmacokinetic parameters of allopurinol or oxypurinol.
In contrast to observations in human beings, allopurinol metabolism is not influenced by diet. Therefore, formation of xanthine-containing calculi in dogs consuming a high-protein diet and receiving allopurinol is probably not attributable to alteration of allopurinol metabolism.
确定饮食是否会影响健康犬静脉注射别嘌醇的代谢。
6只健康雌性比格犬，年龄4.9至5.2岁，体重9.6至11.5千克。
给犬静脉注射别嘌醇（10毫克/千克），同时犬食用基于酪蛋白的10.4%蛋白质（干重）饮食或基于肉类的31.4%（干重）饮食。每次给药后，按时间间隔采集血浆样本，通过高效液相色谱法测定别嘌醇及其活性代谢产物氧嘌呤醇的浓度。使用迭代非线性回归分析程序确定血浆别嘌醇和氧嘌呤醇浓度-时间数据的加权最小二乘最佳拟合曲线。根据这些数据计算药代动力学参数。
比较饮食的影响时，别嘌醇和氧嘌呤醇的药代动力学参数没有差异。
饮食对别嘌醇或氧嘌呤醇的药代动力学参数没有影响。
与人类的观察结果相反，别嘌醇的代谢不受饮食影响。因此，食用高蛋白饮食并接受别嘌醇治疗的犬形成含黄嘌呤结石可能并非由于别嘌醇代谢改变所致。
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