Chow C K
Int J Vitam Nutr Res. 1977;47(3):268-73.
The effects of dietary vitamin E on the important cellular antioxidant defense systems were studied in rat blood. One-month-old male Sprague-Dawley rats were fed a basal vitamin E-deficient diet and supplemented with either none or 45 ppm vitamin E for 4 months. The activity of glutathione (GSH) peroxidase was decreased significantly (p less than 0.05) in the red blood cells and plasma of vitamin E-deficient rats. The level of GSH in the red cells of vitamin E-deficient rats was also significantly decreased. No detectable GSH was found in the plasma of both groups of animals. The activities of catalase and superoxide dismutase were not significantly altered by the status of dietary vitamin E. Similar results were obtained when 2-month-old male rats were fed the respective diets for 3 months. The results suggest that the decreased levels of GSH and GSH peroxidase in the red cells of animals fed a vitamine E-deficient diet may in part contribute to their increased susceptibility to hemolytic agents.
研究了膳食维生素E对大鼠血液中重要细胞抗氧化防御系统的影响。给1月龄雄性斯普拉格-道利大鼠喂食基础维生素E缺乏饮食，并在4个月内不补充或补充45 ppm维生素E。维生素E缺乏大鼠的红细胞和血浆中谷胱甘肽（GSH）过氧化物酶活性显著降低（p<0.05）。维生素E缺乏大鼠红细胞中的GSH水平也显著降低。两组动物的血浆中均未检测到GSH。过氧化氢酶和超氧化物歧化酶的活性未因膳食维生素E状态而显著改变。当给2月龄雄性大鼠喂食相应饮食3个月时，得到了类似的结果。结果表明，喂食维生素E缺乏饮食的动物红细胞中GSH和GSH过氧化物酶水平降低可能部分导致其对溶血剂的易感性增加。
