1-[3-(Aryloxy) propyl]-diamines: a new class of non-steroidal basic antiinflammatory agents. Structure-activity studies: Part II.
作者信息
Hadjipavlou-Litina D
机构信息
Department of Pharmaceutical Chemistry, School of Pharmacy University of Thessaloniki, Greece.
出版信息
Res Commun Mol Pathol Pharmacol. 1997 Mar;95(3):319-29.
PMID:9144838
Abstract
Six substituted aryloxy diamines, synthesized as potential new antiinflammatory agents, were tested in vivo and in vitro in order to evaluate their biological activities. These derivatives reduced significant carrageenin rat paw edema and showed antiproteolytic activity. The in vitro inhibition of soybean lipoxygenase ranged from 41-77%. The results are discussed from the view of structural modifications.
摘要
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