Barka T, Burke G T
Histochem J. 1977 Jul;9(4):453-66. doi: 10.1007/BF01002976.
The enzyme content and the secretory behaviour of normal rat salivary glands were compared with these properties in glands made hypertrophic and hyperplastic by the chronic administration of isoproterenol. The enlarged glands displayed reductions in the concentrations of ribonuclease, deoxyribonuclease and amylase. The secretory behaviour in vivo was similar for all enzymes in both types of glands, but the enlarged glands secreted a lower percentage of their content in vitro. The reduction in amylase activity was shown by immunological techniques to be due to a reduction in the number of enzyme molecules. The reduction in ribonuclease activity was not due to changes in the level of ribonuclease inhibitors.
将正常大鼠唾液腺的酶含量和分泌行为与通过长期给予异丙肾上腺素而肥大和增生的腺体的这些特性进行了比较。增大的腺体中核糖核酸酶、脱氧核糖核酸酶和淀粉酶的浓度降低。两种类型腺体中所有酶的体内分泌行为相似，但增大的腺体在体外分泌的其含量的百分比更低。免疫技术表明淀粉酶活性的降低是由于酶分子数量的减少。核糖核酸酶活性的降低不是由于核糖核酸酶抑制剂水平的变化。
