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[低分子量肝素。在麻醉与复苏中的意义]

[Low molecular weight heparins. Implications in anesthesia and resuscitation].

作者信息

Llau J V, Hoyas L, Ezpeleta J, García-Polit J, Barberá M, Santes M J

机构信息

Servicio de Anestesia-Reanimación y Terapia del Dolor, Hospital Clínico Universitario de Valencia.

出版信息

Rev Esp Anestesiol Reanim. 1997 Feb;44(2):70-8.

PMID:9148359
Abstract

Low molecular weight heparins are a group of drugs that have only recently been introduced in clinical practice. The are widely used for prophylaxis in thromboembolic disease and are being employed increasingly to treat established venous thrombosis. One way in which these drugs are often used is for prophylaxis in the perioperative period for patients at high risk of developing venous thromboembolism, and the anesthesiologist must therefore be familiar with the main aspects of this application. We review pharmacological characteristics of these drugs as well as the literature on low molecular weight heparins, stressing points of main interest to the anesthesiologist and intensive care recovery unit specialist, namely adverse effects (mainly bleeding) and the implications that use of low molecular weight heparin will have on choice of anesthetic (in particular the dilemma of whether to use local/regional anesthesia).

摘要

低分子量肝素是一组最近才引入临床实践的药物。它们广泛用于血栓栓塞性疾病的预防,并越来越多地用于治疗已形成的静脉血栓形成。这些药物常用的一种方式是在围手术期对有发生静脉血栓栓塞高风险的患者进行预防,因此麻醉医生必须熟悉该应用的主要方面。我们回顾了这些药物的药理学特性以及关于低分子量肝素的文献,强调麻醉医生和重症监护恢复室专科医生主要关注的要点,即不良反应(主要是出血)以及使用低分子量肝素对麻醉选择的影响(特别是关于是否使用局部/区域麻醉的困境)。

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