3,4-二氨基吡啶治疗前后兰伯特-伊顿肌无力综合征的刺激单纤维肌电图
Stimulated single-fiber electromyography in Lambert-Eaton myasthenic syndrome before and after 3,4-diaminopyridine.
作者信息
Sadeh M, River Y, Argov Z
机构信息
Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.
出版信息
Muscle Nerve. 1997 Jun;20(6):735-9. doi: 10.1002/(sici)1097-4598(199706)20:6<735::aid-mus11>3.0.co;2-t.
A patient with LEMS unrelated to cancer was studied by stimulated single-fiber electromyography (SFEMG) before and 3 months after the onset of therapy with 3,4-diaminopyridine. All end-plates showed a progressive reduction in blockings and jitter with the increase in stimulation rate. Treatment significantly corrected this feature, but the overall pattern of frequency-improved jitter remained. Such widespread finding is rare but diagnostic for Lambert-Eaton myasthenic syndrome. Stimulated SFEMG can be used to monitor therapy in such patients.
一名与癌症无关的兰伯特-伊顿肌无力综合征（LEMS）患者，在接受3,4-二氨基吡啶治疗前及治疗开始3个月后，接受了单纤维肌电图（SFEMG）检查。随着刺激频率增加，所有终板的阻滞和颤抖均呈进行性减少。治疗显著纠正了这一特征，但频率改善的颤抖总体模式仍然存在。这种广泛存在的表现虽罕见，但对兰伯特-伊顿肌无力综合征具有诊断意义。刺激SFEMG可用于监测此类患者的治疗情况。
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