Schmeller W, Roszinski S, Huesmann M
Klinik für Dermatologie und Venerologie, Medizinische Universität zu Lübeck.
Vasa. 1997;26(1):18-24.
In patients with chronic venous insufficiency erythematous areas in indurated skin (hypodermitis) and non erythematous areas of lipodermatosclerosis were examined.
In 13 patients with venous ulcers a total of 32 localizations in more or less erythematous and indurated ulcer edges were measured. The amount of erythema was taken as an indicator for the extent of hypodermitis. The parameters examined were erythema (a-value), skin temperature (t), laser Doppler flow (LDF), transcutaneous (tcpO2) and intracutaneous oxygen tension (icpO2). According to the amount of erythema the different localizations were separated into two groups: areas with a-values lower than 14,2 were classified as lipodermatosclerosis without or with little erythema, are-as with a-values higher than 14,2 were classified as areas of lipodermatosclerosis with extensive erythema. Identical measurements were also performed in healthy looking skin below the knee.
Skin temperature and LDF were higher in areas with much erythema compared to those with little or no erythema. TcpO2, measured with an electrode temperature of 44 degrees C, was lower in areas with inflammation; tcpO2-values at 37 degrees C and icpO2-values showed no differences in ulcer edges with different amounts of inflammation.
The results show differences of microcirculation between areas of lipodermatosclerosis with and without hypodermitis. These differences did not influence the actual tissue oxygenation in deeper parts in the dermis.
对患有慢性静脉功能不全的患者，检查其硬结皮肤（皮下炎）中的红斑区域和脂肪硬化性皮肤的非红斑区域。
对13例患有静脉溃疡的患者，在或多或少有红斑和硬结的溃疡边缘共32个部位进行测量。红斑量被用作皮下炎程度的指标。所检查的参数包括红斑（a值）、皮肤温度（t）、激光多普勒血流（LDF）、经皮氧分压（tcpO2）和皮内氧分压（icpO2）。根据红斑量，将不同部位分为两组：a值低于14.2的区域被归类为无或有少量红斑的脂肪硬化，a值高于14.2的区域被归类为有广泛红斑的脂肪硬化区域。在膝下外观正常的皮肤也进行了相同的测量。
与红斑少或无红斑的区域相比，红斑多的区域皮肤温度和LDF更高。用44摄氏度电极温度测量的tcpO2在炎症区域较低；37摄氏度时的tcpO2值和icpO2值在炎症程度不同的溃疡边缘没有差异。
结果显示有皮下炎和无皮下炎的脂肪硬化区域之间存在微循环差异。这些差异并未影响真皮深层的实际组织氧合。
