Kutuzova G I, Frank G K, Makeev V Iu, Esipova N G, Polozov R V
Biofizika. 1997 Mar-Apr;42(2):354-62.
Fourier spectra of E. coli promoter DNA sequences have been obtained. The periodical structure of individual promoter sequences is characterized. E. coli promoter sequences are classified according to their Fourier spectra using three feature sets: 1--the number of peaks in Fourier spectra; 2--values of power spectra for promoter primary structures and their similarity with physical periodicities in the backbone of polynucleotide; 3--the presence of blocks made of equal nucleotides. The comparison of Fourier spectra of promoter sequences and corresponding genes is provided. The conclusion that different ways of stabilization of promoter secondary structure in the case of different primary structure periodicities is drawn. The intermittence of AT- and GC-blocks, and variety of Fourier spectra mean DNA hydrate shell in DNA promoters is non-contiguous and non-stable at junction points. Characteristic features of prokaryotic promoters Fourier spectra differ from human promoters.
已获得大肠杆菌启动子DNA序列的傅里叶光谱。对各个启动子序列的周期性结构进行了表征。利用三个特征集根据其傅里叶光谱对大肠杆菌启动子序列进行分类：1 - 傅里叶光谱中的峰数；2 - 启动子一级结构的功率谱值及其与多核苷酸主链中物理周期性的相似性；3 - 由相等核苷酸组成的块的存在情况。对启动子序列和相应基因的傅里叶光谱进行了比较。得出了在不同一级结构周期性情况下启动子二级结构稳定化的不同方式的结论。AT块和GC块的间歇性以及傅里叶光谱的多样性意味着DNA启动子中的DNA水合壳在连接点处是不连续且不稳定的。原核生物启动子傅里叶光谱的特征与人类启动子不同。
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