Jak/Stat信号通路构建的机制。（备注：“Jak/Stat”一般指“Janus激酶/信号转导及转录激活蛋白”信号通路，这是一种细胞内重要的信号传导途径，在免疫系统、细胞增殖、分化等过程中发挥关键作用，这里意译为信号通路构建的机制只是一种较为宽泛的符合语境的翻译，具体含义可能因上下文不同而有所差异）

The house that Jak/Stat built.

作者信息

Levy D E

机构信息

Department of Pathology, NYU School of Medicine, NY 10016, USA.

出版信息

Cytokine Growth Factor Rev. 1997 Mar;8(1):81-90. doi: 10.1016/s1359-6101(96)00054-8.

DOI:10.1016/s1359-6101(96)00054-8

PMID:9174664

Abstract

An international workshop on "Cytokines, Signaling and the Jak/Stat Pathway' organized by Peter C. Heinrich of the Klinikum der RWTH Aachen under the auspices of DFG-Forschergruppe was held in Aachen, Germany, on 4-5 October 1996. In this review David Levy notes that even though some diagrams shown at the meeting displayed more arrows than there were meeting participants, remarkable progress has been made in the unraveling of the complexities of cytokine signal transduction. The central issue in the field of cytokine signaling is specificity, and this issue was addressed through experimental results from biochemical, molecular, and genetic studies of signal transduction pathways.

摘要

1996年10月4日至5日，由亚琛工业大学附属医院的彼得·C·海因里希在德国研究基金会研究小组的支持下组织的“细胞因子、信号传导与Jak/Stat信号通路”国际研讨会在德国亚琛举行。在这篇综述中，大卫·利维指出，尽管会议上展示的一些图表中的箭头比参会人数还多，但在揭示细胞因子信号转导的复杂性方面已经取得了显著进展。细胞因子信号传导领域的核心问题是特异性，而这个问题是通过对信号转导途径的生化、分子和遗传学研究的实验结果来解决的。