滑膜软骨瘤病继发软骨肉瘤。两例报告并文献复习。

Chondrosarcoma secondary to synovial chondromatosis. Report of two cases and a review of the literature.

作者信息

Wuisman P I, Noorda R J, Jutte P C

机构信息

Department of Orthopaedic Surgery, Academic Hospital of the Free University, Amsterdam, The Netherlands.

出版信息

Arch Orthop Trauma Surg. 1997;116(5):307-11.

PMID:9177811

Abstract

Malignant transformation of synovial chondromatosis into chondrosarcoma is unusual. Thirteen cases and one series have been reported; only four of them developed in the hip. The overall survival is about 50%, possibly because of the difficulty of arriving at a correct early diagnosis (radiographically and histologically) and subsequent adequate surgical therapy. We report two patients (ages 30 and 50 years) in whom synovial chondrosarcoma developed in previously excised synovial chondromatosis of the hip. The diagnosis was made with modern imaging techniques (computed tomography and magnetic resonance imaging) and verified by open biopsy. The early recognition allowed a wide limb-saving resection; both patients are disease free 3 and 2 years after surgery.

摘要

滑膜软骨瘤病恶变为软骨肉瘤的情况并不常见。已有13例病例及1个系列报道；其中仅4例发生于髋关节。总体生存率约为50%，这可能是由于难以在早期做出正确诊断（影像学和组织学方面）以及后续进行充分的手术治疗。我们报告了2例患者（年龄分别为30岁和50岁），他们先前已切除髋关节滑膜软骨瘤，之后发生了滑膜软骨肉瘤。通过现代成像技术（计算机断层扫描和磁共振成像）做出诊断，并经开放活检证实。早期识别使得能够进行广泛的保肢切除；两名患者术后3年和2年均无疾病。