Ota M, Kyakumoto S, Sato N
Department of Biochemistry, Iwate Medical University School of Dentistry, Morioka, Japan.
Hum Cell. 1996 Mar;9(1):79-88.
The adenocarcinoma cell line derived from an intercalated ductal epithelium of a human salivary gland (HSG) proliferates autonomously mediated by an epidermal growth factor-(EGF)-like molecule with a molecular weight of 46 kDa and an EGF receptor (EGFR). The c-erbB2 protein, a member of EGFR family was also expressed in HSG cells and was involved in the growth signal pathway of HSG cells as well as EGFR. The autocrine growth is regulated by glucocorticoid and retinoic acid (RA) via their receptors. Retinoic acid receptor (RAR) of HSG cells revealed a transcriptional activity in vivo, and the heterodimerization between RAR and 9-cis retinoic acid receptor (RXR) is requisite for the binding with a specific DNA element termed RA response element in vitro. RXR alpha and RXR beta were cloned from HSG cells, and these RXRs, together with RAR, seemed to play a physiological role in RA signaling in vivo.
源自人唾液腺（HSG）闰管上皮的腺癌细胞系由一种分子量为46 kDa的表皮生长因子（EGF）样分子和表皮生长因子受体（EGFR）介导自主增殖。c-erbB2蛋白是EGFR家族的一员，也在HSG细胞中表达，并参与HSG细胞以及EGFR的生长信号通路。自分泌生长受糖皮质激素和视黄酸（RA）通过它们的受体调节。HSG细胞的视黄酸受体（RAR）在体内显示出转录活性，并且RAR与9-顺式视黄酸受体（RXR）之间的异二聚化对于在体外与称为RA反应元件的特定DNA元件结合是必需的。RXRα和RXRβ从HSG细胞中克隆出来，并且这些RXR与RAR一起似乎在体内RA信号传导中发挥生理作用。
