使用氯氮平治疗帕金森病中左旋多巴诱发的精神病：回顾性研究。

Use of clozapine to treat levodopa-induced psychosis in Parkinson's disease: retrospective review.

作者信息

Widman L P, Burke W J, Pfeiffer R F, McArthur-Campbell D

机构信息

Creighton University/University of Nebraska Combined Department of Psychiatry, Omaha, USA.

出版信息

J Geriatr Psychiatry Neurol. 1997 Apr;10(2):63-6. doi: 10.1177/089198879701000205.

DOI:10.1177/089198879701000205

PMID:9188021

Abstract

Levodopa-induced psychosis can complicate the treatment of Parkinson's disease (PD). In this retrospective, uncontrolled report, we describe our experience treating PD-related psychosis with clozapine, emphasizing those patients treated for longer than 1 year. Twenty-seven patients were treated, 14 for longer than 1 year. Most patients showed a rapid improvement from baseline within 1 month using the Clinical Global Impression and Global Psychosis Rating Scores. Five patients discontinued the drug due to side effects, but only two patients reported side effects after 6 months of treatment. Clozapine appears to be effective in treating PD related psychotic symptoms while not interfering with motor function.

摘要

左旋多巴诱发的精神病会使帕金森病（PD）的治疗变得复杂。在这份回顾性、非对照报告中，我们描述了使用氯氮平治疗帕金森病相关精神病的经验，重点关注治疗时间超过1年的患者。共治疗了27例患者，其中14例治疗时间超过1年。使用临床总体印象和总体精神病评定量表，大多数患者在1个月内从基线水平迅速改善。5例患者因副作用停药，但只有2例患者在治疗6个月后报告有副作用。氯氮平似乎在治疗帕金森病相关精神症状方面有效，同时不干扰运动功能。