Johnson D E, Goldberg M
Fox Chase Cancer Center, Temple University, School of Medicine, Philadelphia, Pennsylvania, USA.
Oncology (Williston Park). 1997 Jun;11(6):781-5; discussion 785-6.
Tumors of the superior pulmonary sulcus (Pancoast tumors) are bronchogenic carcinomas that occur at the thoracic inlet and typically involve, by direct extension, the lower trunks of the brachial plexus, the intercostal nerves, the stellate ganglion, and adjacent ribs and vertebrae. These tumors are rare, comprising 5% of all lung cancers. Treatment of Pancoast tumors has traditionally consisted of preoperative radiation to a dose of 3,000 to 4,500 cGy followed by surgical resection. Overall 5-year survival rates range from 30% to 50%. Even if treatment achieves local disease control, distant failure (brain or bone) is common. Recent treatment efforts have focused on the use of induction chemoradiation followed by surgery and further chemotherapy. This combined-modality approach may become the new treatment paradigm for Pancoast tumors.
肺上沟瘤（潘科斯特瘤）是发生于胸廓入口处的支气管源性癌，通常通过直接蔓延累及臂丛下干、肋间神经、星状神经节以及相邻的肋骨和椎体。这些肿瘤较为罕见，占所有肺癌的5%。传统上，肺上沟瘤的治疗包括术前给予3000至4500厘戈瑞的放射剂量，随后进行手术切除。总体5年生存率在30%至50%之间。即使治疗实现了局部疾病控制，远处转移（脑或骨）也很常见。最近的治疗努力集中在采用诱导放化疗，随后进行手术及进一步化疗。这种综合治疗方法可能会成为肺上沟瘤的新治疗模式。
