Ohtsuka M, Yamashita Y, Doi M, Hasegawa S
Dept of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
Eur Respir J. 1997 Jun;10(6):1405-7.
Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.
已知丙硫氧嘧啶（PTU）可引起血管炎这一罕见并发症。我们报告了1例在接受PTU治疗时出现肺泡出血和血尿的患者。血清抗中性粒细胞胞浆抗体（ANCA）髓过氧化物酶（MPO）特异性抗体（MPO-ANCA）呈阳性。停用PTU后所有症状完全缓解。与髓过氧化物酶特异性抗中性粒细胞胞浆抗体相关的肺泡出血或肺肾综合征可能是丙硫氧嘧啶治疗的一种新并发症。
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