Borges-Neto S, Shaw L J, Kesler K L, Hanson M W, Peterson E D, Morris E I, Coleman R E
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
J Nucl Cardiol. 1997 May-Jun;4(3):189-94. doi: 10.1016/s1071-3581(97)90078-7.
The purpose of this study was to compare the incremental value of clinical information, electrocardiographic data, myocardial perfusion imaging, and radionuclide angiography for predicting severe coronary artery disease at a single testing interval. Clinical information, treadmill exercise studies, radionuclide angiography, and myocardial perfusion imaging are important predictors of severe coronary artery disease. However, the relative and absolute diagnostic importance of each of these methods has not been addressed at a single testing interval.
A same-day rest/treadmill exercise perfusion and function study was performed in 167 patients within 90 days of coronary angiography. A multivariable regression model was used to assess the independent informational content of these predictors. Clinical and electrocardiographic data were related strongly to the presence of severe coronary artery disease (chi2 = 12.2 and p < 0.001; chi2 = 11.8 and p < 0.001, respectively). Combined perfusion and functional studies contributed 31% of the diagnostic information beyond that provided by clinical and electrocardiographic data alone (p < 0.05).
These data demonstrate that combined studies of myocardial perfusion and left ventricular function are able to improve prediction of the extent of coronary artery disease, even when clinical and electrocardiographic data are also available.
本研究的目的是比较临床信息、心电图数据、心肌灌注成像和放射性核素血管造影在单个检测间隔期预测严重冠状动脉疾病的增量价值。临床信息、平板运动试验、放射性核素血管造影和心肌灌注成像都是严重冠状动脉疾病的重要预测指标。然而，这些方法各自相对和绝对的诊断重要性在单个检测间隔期尚未得到探讨。
在冠状动脉造影90天内，对167例患者进行了同日静息/平板运动灌注及功能研究。采用多变量回归模型评估这些预测指标的独立信息含量。临床和心电图数据与严重冠状动脉疾病的存在密切相关（分别为χ² = 12.2，p < 0.001；χ² = 11.8，p < 0.001）。灌注与功能联合研究提供了超出临床和心电图数据单独提供的31%的诊断信息（p < 0.05）。
这些数据表明，即使有临床和心电图数据，心肌灌注与左心室功能的联合研究仍能够改善对冠状动脉疾病程度的预测。
