Hirabayashi Y, Munakata Y, Saitou S, Sasaki T
Department of Internal Medicine, Tohoku University School of Medicine.
Nihon Rinsho. 1997 Jun;55(6):1455-61.
The studies for autoantibody-associated V genes have failed to find any V gene which might be specific for pathogenic autoantibodies in humans; Namely, both normal subjects and patients have immunoglobulin V genes which can encode autoantibodies. Also single V gene can encode antibodies for both foreign antigens and autoantigens. However, some germline V genes such as V3-7 and VH4-21 are preferentially used for autoantibodies and may be regarded as prototype V genes for autoantibodies. Although somatic mutation in V genes is characteristic in IgG autoantibodies, 0-81 idiotype-positive IgM antibodies, which may be precursor B cells for pathogenic anti-DNA antibody also included many somatic mutations in VH genes, indicating an intrinsic abnormality in B cell development in SLE. Some studies also indicated an abnormal V gene repertoire in autoimmune states. These results may be attributed to dysregulation of autoantibody-associated B cell development.
针对自身抗体相关V基因的研究未能找到任何可能对人类致病性自身抗体具有特异性的V基因；也就是说，正常人和患者都有可编码自身抗体的免疫球蛋白V基因。而且单个V基因可以编码针对外来抗原和自身抗原的抗体。然而，一些种系V基因，如V3-7和VH4-21，优先用于自身抗体，可被视为自身抗体的原型V基因。虽然V基因中的体细胞突变是IgG自身抗体的特征，但0-81独特型阳性IgM抗体（可能是致病性抗DNA抗体的前体B细胞）在VH基因中也包含许多体细胞突变，这表明系统性红斑狼疮中B细胞发育存在内在异常。一些研究还表明自身免疫状态下V基因库异常。这些结果可能归因于自身抗体相关B细胞发育的失调。
