Hashizume Y
Acta Pathol Jpn. 1977 May;27(3):409-19.
In the present report five autopsy cases of adult aqueductal stenosis arising from granular ependymitis have been reported. In all cases the aqueduct was obstructed or markedly stenosed by subependymal gliosis mainly consisting of fibrillary astroglia. Islands and tubules of ependymal cells were embedded in a dense bed of subependymal glia with the loss of ependyma. The walls of all ventricles showed the same pathologic findings with the aqueduct, although the degree was not so marked. Such findings support the view that some type of chronic infection produces the aqueductal stenosis, because it is impossible to produce such diffuse ependymal changes by congenital anomaly. It is of particular importance in this report that all cases were adults. In comparison with the microscopical findings in cases of aqueductal stenosis of infants and children arising from granular ependymitis, which have been reported in the literature, there were no principle differences between infants, children and adults.
在本报告中，报道了5例因颗粒性室管膜炎导致成人导水管狭窄的尸检病例。在所有病例中，导水管均被主要由纤维性星形胶质细胞组成的室管膜下胶质增生阻塞或明显狭窄。室管膜细胞岛和小管嵌入致密的室管膜下胶质床中，室管膜消失。所有脑室壁均显示出与导水管相同的病理表现，尽管程度不那么明显。这些发现支持了某种类型的慢性感染导致导水管狭窄的观点，因为先天性异常不可能产生如此弥漫性的室管膜改变。本报告中特别重要的是所有病例均为成年人。与文献中报道的因颗粒性室管膜炎导致婴幼儿导水管狭窄病例的显微镜检查结果相比，婴幼儿、儿童和成年人之间没有原则性差异。
