Tong S, Ingenito S, Frasier I D, Sica A L, Gootman N, Gootman P M
Department of Physiology, SUNY Health Science Center at Brooklyn 11203, USA.
J Auton Nerv Syst. 1997 Jun 6;64(2-3):162-5. doi: 10.1016/s0165-1838(97)00020-9.
The effects of partial autonomic denervation of the heart rate and Q--T interval were examined during maturation in swine. Four groups of newborns were prepared: right stellate ganglionectomy (RSG), left stellate ganglionectomy (LSG), right cardiac vagotomy (RCV) and sham-operated. Swine were studied postsurgically for eight weeks. Unexpected deaths of unknown cause occurred in five of the 20 denervated swine but in none of the 10 sham-operated controls. Prolongation of the Q--T interval was greatest in RSG animals and least in RCV as compared to controls. The results indicate that we have successfully developed an animal model of a long Q--T syndrome in swine.
在猪的生长发育过程中，研究了心脏自主神经部分去神经支配对心率和Q-T间期的影响。将新生猪分为四组：右侧星状神经节切除术（RSG）、左侧星状神经节切除术（LSG）、右侧心脏迷走神经切断术（RCV）和假手术组。术后对猪进行了八周的研究。20只去神经支配的猪中有5只因不明原因意外死亡，而10只假手术对照组均未出现死亡。与对照组相比，RSG组动物的Q-T间期延长最明显，RCV组最不明显。结果表明，我们成功建立了猪长Q-T综合征的动物模型。
