Pollak P
Clinique reurologique Centre hospitalier universitaire de Grenoble.
Rev Prat. 1997 May 15;47(10):1068-76.
The loss of dopaminergic melanized neurons of the substantia nigra is the main lesion of Parkinson's disease. This cell death, of unknown origin, is accompanied by the formation of free radicals and the occurrence of oxidative stress. The nigro-striatal dopaminergic hypoactivity induces a disinhibition of the subthalamo-pallidal structures responsible for a frontal cortex hypoactivity, at the origin of akinesia. Levodopa is the most effective treatment of Parkinson's disease, but exposes to motor complications that new therapeutic strategies try to limit. The neurosurgical treatment, especially deep brain stimulation, is applied to few selected patients.
黑质中多巴胺能黑素化神经元的丧失是帕金森病的主要病变。这种不明原因的细胞死亡伴随着自由基的形成和氧化应激的发生。黑质纹状体多巴胺能活性降低导致对负责额叶皮质活动减退的丘脑底核 - 苍白球结构的去抑制，从而引发运动不能。左旋多巴是帕金森病最有效的治疗方法，但会引发运动并发症，新的治疗策略试图对此加以限制。神经外科治疗，尤其是深部脑刺激，仅适用于少数选定的患者。
