Bottlender R, Schütz C, Möller H J, Soyka M
Ludwig-Maximilians-University, Munich, Germany.
Pharmacopsychiatry. 1997 May;30(3):108. doi: 10.1055/s-2007-979492.
Zolpidem is a non-benzodiazepine hypnotic whose actions are mediated at the central GABA-A receptor complex. It has been assumed that zolpidem has a lower potential for abuse than benzodiazepines. However, there is growing evidence form clinical and animal pharmacology that the potential for dependence on zolpidem should not be underestimated (1). In human laboratory studies, abuse liability seemed to be similar to triazolam (2). Animal models suggest that the drug even had higher reinforcing properties than any benzodiazepine tested (3). In the following, a case of zolpidem abuse and dependence is described. The patient had a history of substance abuse. The observed tolerance-related events and withdrawal symptoms were comparable to those maintained by benzodiazepines.
唑吡坦是一种非苯二氮䓬类催眠药，其作用通过中枢γ-氨基丁酸A（GABA-A）受体复合物介导。人们一直认为唑吡坦的滥用可能性低于苯二氮䓬类药物。然而，临床和动物药理学越来越多的证据表明，不应低估对唑吡坦产生依赖的可能性（1）。在人体实验室研究中，滥用倾向似乎与三唑仑相似（2）。动物模型表明，该药物甚至比所测试的任何苯二氮䓬类药物具有更高的强化特性（3）。以下描述一例唑吡坦滥用和依赖病例。该患者有药物滥用史。观察到的与耐受性相关的事件和戒断症状与苯二氮䓬类药物所致者相当。
