Murai Y, Nakajima Y, Ishii A, Moroi A, Takahashi A, Jyo T
Department of Respiratory Medicine, Tokyo Metropolitan Tama Geriatric Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Apr;35(4):381-5.
We examined survival in 53 patients over 60 years old who had chronic obstructive pulmonary disease, and whose FEV1 was less than 60% of the forced vital capacity and was less than 60% of the predicted value. They comprised 34 men and 19 women. The mean age was 75.2 years. The %FEV1 was 39.0% and the body mass index was 19.0. Neither age %FEV1, nor body mass index differed significantly between men and women. However, the number of cigarettes smoked per day, the number of years of cigarette smoking, and the Brinkman index were higher in men than in women. The Brinkman index was 1255.0 in men and 617.8 in women (p = 0.0001). For the group as a whole, the 5-year survival rate was 65% and the 10-year survival rate was 35%. The survival rate of men did not differ from that of women. Survival and %FEV1 did not differ between men and women, despite the significant difference in Brinkman index, which suggests that women were more susceptible to the effects of cigarette smoking than men. Age, one tenth of %FEV1, and body mass index less than 19 were found to be independent predictors of mortality (proportional hazards analysis, p = 0.044, 0.019, and 0.024, respectively). The 5-year survival rate were as follows: 85% in patients less than 75 years of age, 50% in patients more than 75 years of age, 25% in patients with a %EFV1 less than 30%, 80% in patients with a %FEV1 of 30% to 49%, 62% in patients with a %FEV1 of 50% to 60%, 50% in patients with a body mass index of less than 19, and 83% in patients with a body mass index of more than 19.
我们对53名60岁以上患有慢性阻塞性肺疾病的患者进行了生存情况研究,这些患者的第一秒用力呼气容积(FEV1)小于用力肺活量的60%且低于预测值的60%。其中包括34名男性和19名女性。平均年龄为75.2岁。FEV1百分比为39.0%,体重指数为19.0。男性和女性在年龄、FEV1百分比以及体重指数方面均无显著差异。然而,男性每天吸烟支数、吸烟年限以及布林克曼指数均高于女性。男性的布林克曼指数为1255.0,女性为617.8(p = 0.0001)。对于整个研究组而言,5年生存率为65%,10年生存率为35%。男性和女性的生存率并无差异。尽管布林克曼指数存在显著差异,但男性和女性在生存情况与FEV1百分比方面并无差异,这表明女性比男性更容易受到吸烟影响。年龄、FEV1百分比的十分之一以及体重指数小于19被发现是死亡率的独立预测因素(比例风险分析,p值分别为0.044、0.019和0.024)。5年生存率如下:75岁以下患者为85%,75岁以上患者为50%,FEV1百分比小于30%的患者为25%,FEV1百分比为30%至49%的患者为80%,FEV1百分比为50%至60%的患者为62%,体重指数小于19的患者为50%,体重指数大于19的患者为83%。