Bruyn R P, van Veen M M, Kremer H, Scheltens P H, Padberg G W
Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
Clin Neurol Neurosurg. 1997 May;99(2):87-90. doi: 10.1016/s0303-8467(97)00602-1.
Autosomal dominant familial spastic paraparesis (AD-FSP) is a genetically heterogeneous disorder of the central nervous system characterized by a progressive spasticity of the legs. One gene causing AD-FSP (FSP1) has recently been mapped to chromosome 14q, another gene (FSP2) to chromosome 2p, and a third gene (FSP3) to chromosome 15q. We now report a large Dutch family with AD-FSP without linkage to any of these chromosomes, providing evidence for a fourth locus (FSP4).
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