重组人粒细胞集落刺激因子（R-metHuG-CSF）成功治疗自身免疫性中性粒细胞减少症。
Successful treatment of autoimmune neutropenia with recombinant human granulocyte-colony stimulating factor (R-metHuG-CSF).
作者信息
Krishnan K, Ross C W, Bockenstedt P L, Adams P T
机构信息
Division of Hematology-Oncology, East Tennessee State University, Johnson City, Tennessee, USA.
出版信息
Clin Lab Haematol. 1997 Jun;19(2):105-9. doi: 10.1046/j.1365-2257.1997.d01-275.x.
Autoimmune neutropenia (AIN) is characterized by antibody mediated peripheral destruction of neutrophils. Since there is no effective treatment, antibiotics have to be used frequently for recurrent infections. Five selected patients with serologically proven AIN were treated with r-metHuG-CSF at 5-8 micrograms/kg body weight (300-480 micrograms) daily; the dose and frequency of r-metHuG-CSF was reduced after neutrophil counts above 1.0 x 10(9)/l were obtained. R-metHuG-CSF is effective in AIN and causes a sustained rise in ANC which can be maintained on a low dose administered twice or thrice weekly.
自身免疫性中性粒细胞减少症（AIN）的特征是抗体介导的中性粒细胞外周破坏。由于没有有效的治疗方法，对于反复感染不得不频繁使用抗生素。选取了5例血清学确诊的AIN患者，以每日5 - 8微克/千克体重（300 - 480微克）的剂量给予重组甲硫氨酸人粒细胞集落刺激因子（r-metHuG-CSF）治疗；在中性粒细胞计数达到1.0×10⁹/升以上后，降低r-metHuG-CSF的剂量和频率。r-metHuG-CSF对AIN有效，可使绝对中性粒细胞计数（ANC）持续升高，且通过每周两次或三次的低剂量给药即可维持。
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