瑞斯塔可林与氟卡尼对各种心脏跨膜钾电流影响的比较。
Comparison of the effects of restacorin and flecainide on various cardiac transmembrane potassium currents.
作者信息
Németh M, Virág L, Varró A, Papp J G
机构信息
Department of Pharmacology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
Acta Physiol Hung. 1996;84(3):317-8.
The effect of restacorin (5 microM) and flecainide (5 microM) on the transmembrane ionic currents was compared in dog and rabbit ventricular muscle by applying the conventional microelectrode and patch-clamp techniques. Neither restacorin nor flecainide influenced significantly the ATP-sensitive and inward rectifier potassium currents. Flecainide moderately decreased the amplitude of the transient outward current while restacorin did not change this current. The delayed rectifier potassium current was depressed markedly by flecainide and moderately by restacorin. These results suggest that although flecainide and restacorin cause similar changes in the various transmembrane ionic currents, there are some differences between the effects of the two antiarrhythmic compounds.
运用传统微电极和膜片钳技术，比较了瑞斯塔考林（5微摩尔）和氟卡尼（5微摩尔）对犬和兔心室肌跨膜离子电流的影响。瑞斯塔考林和氟卡尼均未对ATP敏感性钾电流和内向整流钾电流产生显著影响。氟卡尼适度降低了瞬时外向电流的幅度，而瑞斯塔考林对此电流无影响。延迟整流钾电流被氟卡尼显著抑制，被瑞斯塔考林中度抑制。这些结果表明，尽管氟卡尼和瑞斯塔考林在各种跨膜离子电流上引起相似的变化，但这两种抗心律失常化合物的作用之间仍存在一些差异。
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