偏头痛基因的探寻。

The quest for migraine genes.

作者信息

Terwindt G M, Haan J, Ophoff R A, Frants R R, Ferrari M D

机构信息

Department of Neurology, Leiden University Medical Centre, The Netherlands.

出版信息

Curr Opin Neurol. 1997 Jun;10(3):221-5. doi: 10.1097/00019052-199706000-00009.

DOI:10.1097/00019052-199706000-00009

PMID:9229129

Abstract

Research into the genetics of migraine remains difficult because of the involvement of polygenetic and environmental factors. The discovery of the gene for familial hemiplegic migraine on chromosome 19p 13 is an important step forward. This brain specific P/Q-type calcium channel alpha 1-subunit gene opens new avenues for studying the genetics of migraine, the pathophysiology of the onset of migraine attacks and the development of novel specific prophylactic drugs.

摘要

由于偏头痛涉及多基因和环境因素，对其遗传学的研究仍然困难重重。19号染色体短臂1区3带（19p 13）上家族性偏瘫性偏头痛基因的发现是向前迈出的重要一步。这个脑特异性P/Q型钙通道α1亚基基因，为研究偏头痛遗传学、偏头痛发作的病理生理学以及新型特异性预防药物的研发开辟了新途径。